Anesthesiology

Physics and Anesthesiology

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(A) 2% volatile agent, 70% nitrous oxide, 28% Oxygen

 

(B) 3.1% volatile agent (blue) following 50% nitrous oxide transfer to blood from alveolar volume

 

(C) 2.7% volatile agent (blue) following 2nd breath

a

 

 

10This graph illustrates (by simulation analysis) the increase in FA/FI rate of rise associated with proportional alveolar ventilation and cardiac output increases. The theoretical curves agree with experimental data (see original citation)  The relatively small effect in FA/FI rate of rise, as elaborated below, might be expected for perfusion enhancement to all tissues.  However the effect may be greater if preferential perfusion enhancement occurs to vessel-rich tissue and the process in general is dependent on the use of the relatively more soluble volatile agents.   Primary source:as noted in reference 10, Eger, EI II, Bahman, SH, Munson, ES: Effect of age on the rate of increase of alveolar anesthetic concentration. Anesthesiology 35: 365-372.  1971.

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