Coagulation

Chapter 25: Drugs that Influence Coagulation

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Drugs and Blood Coagulation

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Blood Coagulation: Mechanisms

Anticoagulant Drugs: Pharmacology

Fibrolytic Drugs

Antithrombotic Agents- Antiplatelet Drugs

Pharmacological Management of Thrombosis

 

Blood Coagulation: Mechanisms

Blood Coagulation Cascade: Proposed Model

 

 

Clotting Factors: Drug Target Sites
Factor/Component also called Target
I Fibrinogen  
II Prothrombin Heparin (IIa); Warfarin (synthesis)
III Tissue Thromboplastin  
IV Calcium  
V Proaccelerin  
VII Proconvertin Heparin (VIIa); Warfarin (synthesis)
VIII Antihemophilic globulin (AHG)  
IX Christmas factor, plasma thromboplastin component (PTC) Heparin (IXa); Warfarin (synthesis)
X Stuart-Prower factor Heparin (IXa); Warfarin (synthesis)
XI Plasma thromboplastin antecedent (PTA)  
XII Hageman factor  
XIII Fibrin-stabilizing factor  
Proteins C and S

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Warfarin (synthesis)
Plasminogen

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Thrombolytic enzymes, aminocaproic acid

Coagulation and Fibrinolysis: Regulation

Anticoagulant Drugs: Pharmacology

Heparin

 

 

Warfarin & Coumarin

Coumarin

 

Warfarin

 

 

Fibrolytic Drugs

Antithrombotic -- Antiplatelet Drugs

Aspirin

 

Ticlopidine

 

Pharmacological Management of Thrombosis

 Drugs Used in Bleeding Disorders

Plasma Fractions-- Bleeding due to factor deficiencies

Fibrolytic Inhibitors:aminocaproic acid

 

Aminocaproic Acid

 

Serine Protease Inhibitors: Aprotinin

 

Primary Reference: O'Reilly, R.A. Drugs Used in Disorders of Coagulation, in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, pp 916-940
Handlin, R.I. Bleeding and Thrombosis, In Harrison's Principles of Internal Medicine 14th edition, (Isselbacher, K.J., Braunwald, E., Wilson, J.D., Martin, J.B., Fauci, A.S. and Kasper, D.L., eds) McGraw-Hill, Inc (Health Professions Division), 1998, pp 339-344.

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